In order to determine the distribution variation of groundwater quality in the reclaimed water irrigation area of Beijing, the geostatistics method and ArcGIS9.3 module were used. Based on the normal distribution testing and global trends, the optimal geostatistical interpolation and optimal variogram models for each index were sampled, and the effects of artificial factors and space structure on the water quality index in the reclaimed water irrigation area were determined. The influence of human activities and structural factors on the water quality indicators of groundwater were determined using variability intensity and the nugget effect. The results showed that nitrate content was the water quality indicator in the groundwater that was most sensitive to human activities and could be used as an indicating factor to study groundwater pollution in the study area. In combination with the temporal and spatial variation of groundwater nitrate nitrogen in the study area, it was discovered that the amplification of nitrate nitrogen in the reclaimed water core irrigation area was far less than that in the non-core area. The reasons for such characteristics were vadose zone structure and human activity. The proposed results for groundwater Nitrate-nitrogen distribution can be used to quantify groundwater pollution risk and promote the utilization of wastewater.