This study examines the dynamics of indoor air quality in an office environment within a metropolis, with a specific focus on particulate matter (PM), formaldehyde, and total volatile organic compounds (TVOCs). The levels of PM concentrations stay constant at a value of 13.9±2.9 μg/m3 for PM2.5 throughout working hours, with a significant impact on human activities. The formaldehyde concentration inside increases thrice during 8 hours, from 9±5 μg/m3 to 27±14 μg/m3, primarily from furniture and electronics. The total volatile organic compounds (TVOCs) levels significantly increase from 0.050±0.044 μg/m3 at 8.00 to 0.14±0.11 μg/m3 at 15.00, which can be attributed to indoor contaminants such as plastics and consumer items. PM concentrations exhibit seasonal fluctuations, with higher levels observed during colder months (37±5 μg/m3 for PM2.5 in December and 8±1 μg/m3 for PM2.5 in August in the office, mainly due to outdoor contribution. Analysis of settled dust indicates a varied composition, suggesting the presence of both building materials and human activity. Employees exhibit symptoms consistent with Sick Building Syndrome, with a higher prevalence among females. The results emphasize the significance of dealing with variations in indoor air quality and identifying the causes that affect the health of occupants and the well-being of the workplace.