The results of the integration of zinc oxide (ZnO) nanoparticles into cellulose acetate (CA) ultrafiltration membranes were analyzed and discussed. ZnO was added to the polymeric solution, and the membranes were synthesized using the phase inversion method. Herein, a novel resistant ultrafiltration (UF) membrane for pollutant remediation was developed using a blending method that combines the flexibility of cellulose acetate with ZnO NPs. X-ray diffraction, high-resolution transmission electron microscopy, scanning electron microscopy, dynamic scattering light, and UV–vis spectrophotometry were used to characterize the catalyst. The zinc oxide nanoparticles were used as a photocatalyst for the decomposition of Malachite. The effects of irradiation time, loading catalyst doses, and the initial concentration of Malachite on photocatalytic degradation efficiency were optimized.