We studied the feasibility of two advanced oxidation processes (AOPs), including the Fenton and ozonation processes, and a conventional sequence batch reactor (SBR) for treating wastewater from polyurethane manufacturing. The results showed that the SBR achieved a COD removal rate of 93.3% when the influent COD concentration was 1,600 mg·L^-1, which was 22.1 and 522.1% higher than the best results by the Fenton (H₂O₂/COD = 0.0623 mM·g^-1 and Fe²⁺/COD = 0.0102 mM·g^-1) and ozonation (1 g·L^-1, 45 min) processes. A COD removal rate of 90.6% for SBR was achieved after an aeration time of 12 h, and the COD degradation rate was similar to that of a zero-order reaction. A study of the SBR drivers suggested that air stripping and self-volatilization contributed to the higher COD removal rates obtained in this process. This study shows that a single SBR is practical for treating small amounts of polyurethane manufacturing wastewater, and that it had a higher ability to remove COD and resist feeding load shock than the other methods tested. But the potential risks of volatile organic compounds (VOCs) stripping out during the aeration process should be of concern.