Cirata Dam is one of the dams in West Java, Indonesia, which has significant resources of endemic fish potential from adjacent rivers, as well as fish introduction from other regions or countries. Unfortunately, the production of fishing in these dams has decreased significantly every year due to unregulated fishing activities, water pollution caused by the feed from aquaculture activities, as well as domestic and industrial wastes discharged into the waters. This study analyzes the depletion of fish resources due to fishing and pollution at these sites. Methods used in this research are the bio-economic logistic standard and Gompertz model, to measure the impact of fishing on the dynamics of fish resources, and linear as well as non-linear regression to obtain the coefficient of pollution on production. The depletion of fish resources calculated by Anna model modification. The result shows that the depletion rate of Cirata’s fish, varies in a year with an average depletion of 25% during the year of observation with standard model for analyzing fishing activities intervention alone. Combined with pollution, the rate of depletion is increased. The implication of the MSY or MEY management instruments is required to control the fish resources.