In many cases, water intended for drinking purposes must be treated in order to meet the requirements of Regulation of the Government of the Slovak Republic No. 354/2006 on drinking water. There is a tendency to find more efficient and cost-effective materials and technologies used in water treatment. The goal of this study is to compare activated natural zeolite-clinoptilolite with activated filtration sand and the imported material Birm (from the Clack Corporation, USA) in removal of iron and manganese from water. Obtained results carried out in the water treatment plant in Holíč prove that Klinopur-Mn is suitable for removal of iron and manganese from water and is comparable with other imported materials.