ORIGINAL RESEARCH
Quercetin Reduces Prooxidant Action
of Organometallic Compounds on Liposome
Membranes Irradiated with UV
J. Gabrielska 1*, M. Soczyńska-Kordala 2, S. Przestalski 1
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1 Department of Physics and Biophysics, Agricultural University, Norwida 25, 50-375 Wrocław, Poland
2 Department of Fruits, Vegetables and Cereals Technology, Agricultural University, Norwida 25, 50-375 Wrocław, Poland
Pol. J. Environ. Stud. 2004;13(5):509-514
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ABSTRACT
We studied the effects of UV radiation on the degree of phosphatidylcholine (PC) liposome membrane
oxidation in the presence of such toxic organometallic compounds (TOC) as diphenyltin dichloride (DPhT),
triphenyltin chloride (TPhT), dibutyltin dichloride (DBT), tributyltin chloride (TBT), triphenyllead chloride
(TPhL) and tributyllead chloride (TBL). PC liposome oxidation was also investigated in the presence of quercetin
(Que) and equimolar mixtures of Que and TOC in order to determine the protective properties of this
natural antioxidant with respect to liposome membrane oxidation induced by UV light. Concentration of the
compounds studied was 10 µM. The degree of liposome oxidation was measured using the TBARS (Thiobarbitutric
Reactive Substances) test. The sequence thus obtained of relative induction of PC oxidation due to
TOC was as follows: TBT > TPhT = DBT > DPhT = TPhL > TBL. The results of studies with Que indicate
its high efficacy in the antioxidative action of equimolar mixtures of Que and TOC.
From our study it follows that quercetin forms complexes both with phenyl- and butyl- tin and lead
compounds. A high antiradical (towards DPPH radical) activity of the associates with respect to the activity
of quercetin alone was also found. This result can partly explain the antioxidative properties of Que in the
studied solution, connected with their antiradical action and chelating posibility towards the organometallic
compounds studied.
A factor that differentiates the antioxidant activity of the complexes Que-TOC is probably their differentiated
location in the liposome membrane bilayer.