The aim of the work is to investigate water quality in the industrial region of the Ural (Russia) according to the main parameters. The study was conducted in 2021 in 10 cities of the Sverdlovsk region. Water samples were taken from artesian wells and centralized water supply systems. Water samples were tested for pH value, hardness, mineralization, nitrate concentration, and the content of heavy metals (voltammetry method). A high content of nitrates was established for 2 towns: Verkhnyaya Pyshma (p≤0.05 to the norm) and Degtyarsk (3 times more than the norm, p≤0.01). In terms of cadmium concentration, water samples from Nizhny Tagil and Degtyarsk are 8 times the norm (p≤0.01), from Bogdanovich - 4 times (p≤0.05), from Serov - 6 times (p≤0.01), from Kamensk-Uralsky - 10 times (p≤0.001). In terms of lead concentration, samples from 5 cities are 1.2-1.5 times higher than the norm (p≤0.05), from Serov - 7 times higher (p≤0.01), and from Yekaterinburg - 2.5 times higher (p≤0.05). Most (6 of 10) cities have shown high levels of water pollution by heavy metals.