ORIGINAL RESEARCH
Neuropharmacological Evaluation and Antioxidant Potential of Aloe Barbadensis, Capparis Spinosa and Senegalia Senegal Extract in Mice
 
More details
Hide details
1
Department of Pharmacology and Toxicology, Unaizah College of Pharmacy, Qassim University, Saudi Arabia
 
 
Submission date: 2023-11-05
 
 
Final revision date: 2023-12-05
 
 
Acceptance date: 2023-12-21
 
 
Online publication date: 2024-04-25
 
 
Publication date: 2024-05-23
 
 
Corresponding author
Sulaiman Mohammed Alnasser   

Department of Pharmacology and Toxicology, Unaizah College of Pharmacy, Qassim University, Saudi Arabia
 
 
Pol. J. Environ. Stud. 2024;33(4):4031-4042
 
KEYWORDS
TOPICS
ABSTRACT
Aloe barbadensis, Capparis spinosa, and Senegalia senegal are popular in traditional medicine due to their therapeutic effects. We aimed to assess the neuropharmacological potential of their extracts, including the impact on pain-relief, anxiety, depression, muscle relaxation, and motor coordination. BALB/c mice were administered with standardized doses of A. barbadensis, C. spinosa, and S. senegal extracts, and their behavior was recorded through various neurobehavioral tests. The antioxidant potential of the extracts was also evaluated by DPPH assay. A differential response was observed among the three extracts for analgesic activity. A. barbadensis showed an increase in latency time after an increase in dose, while C. spinosa and S. senegal exhibited a biphasic response. A. barbadensis showed very good anxiolytic effects and best anti-depression effects. S. senegal exhibited the best antioxidant activity, followed by A. barbadensis and C. spinosa. This shows that these plants could counteract oxidative stress and protect neurons from potential damage caused by free radicals. The observed anxiolytic, muscle relaxant effects, and enhanced antioxidant potential of the selected plants in BALB/c mice, indicate their potential therapeutic value in neuroprotective strategies and the treatment of oxidative stress-related neurological disorders. However, further investigations into their underlying mechanisms and long-term safety profiles are suggested before considering their translation into clinical applications.
eISSN:2083-5906
ISSN:1230-1485
Journals System - logo
Scroll to top