In this study, the electrocatalysis method is used to degrade polyacrylamide (PAM) from wastewater. This method can degrade PAM rapidly and effectively, and it has no secondary pollution but has clean and environmental protection. The Box–Behnken design of response surfaces is used to optimize the PAM degradation experiment of wastewater. In accordance with the regression analysis results, the second-order polynomial fitting model is significant. The best conditions for the experiment are a current density of 58.8 mA/cm2, an electrode plate spacing of 3.07 cm, initial pH of the solution of 6.73 and reaction time of 2.225 h. The COD removal rate reaches 92.7%, and the predicted value is 92.24%. Therefore, electrocatalytic degradation of PAM has a good application prospect.