Hazardous and toxic waste (HW) is waste that cannot be decomposed and can have a negative impact on the surrounding environment. Semarang City is one of the large cities in Indonesia that does not yet have specific waste management for hazardous and toxic materials, especially in the residential and office sectors. This research aims to simulate the management of hazardous and toxic waste using a Material Recovery Facility (MRF) in the residential and office sectors. This paper analyzes the current situation of processing facilities and plans the capacity for managing toxic hazardous waste using MRF. This research uses an analysis of existing hazardous and toxic waste management, followed by population projections and the resulting waste generation. Waste in Semarang City in 2031 amounted to 862.65 t/d, which includes all types of city waste, including HWs, which can be recycled at the MRF with an efficiency of 73.03%. The composition of residential waste is dominated by infectious types of B3 waste at 82.9%, followed by toxic t ypes of B3 waste at 6.9%, flammable at 5.8%, and corrosive at 4.4%. Meanwhile, the largest amount of B3 waste from the office sector is generated from corrosive B3 waste, namely 44.9%. This is followed by flammable B3 waste at 20.1%, toxic waste a t 1 9.6%, and infectious waste at 15.4%. The planned MRF will improve waste processing performance and will not impact land in landfills. MRF helps improve development in Semarang City by greatly reducing the burden of waste problems. Apart from that, MRF is a sustainable system that has great economic value for the Semarang City government at the time of its implementation.