The synthesis of growth-promoting compounds for better yield of food crops and benefit to mankind has always been a desire of plant scientists, but the use of hazardous solvents in the process and the low yield of such organic compounds have been major challenges. In this research, naphthyl acetic acid-based compounds were prepared using green chemistry protocols, including microwaves and environmentally friendly solvents. The prepared compounds were chemically characterized to be Schiff bases and ethyl esters. The prepared compounds were assessed for the in vitro growth-promoting capability of Bougainvillea glabra explants on MS basal medium. The concentration range of 1, 10, and 100 μM of the compounds was used and the comparison was made with standard thidiazuron (TDZ). The B-10 and B-13 compounds among Schiff bases and B-11 and B-14 compounds among ethyl esters (derived from naphthyl acetic acid moieties) produced significantly better growth response as compared to commercial standard at 1 μM concentration in B.glabra explants. Increased catalase and superoxide dismutase levels in explants treated with synthesized compounds indicated stress alleviation in explants through antioxidant enzyme production.