Safflower is a climate-resilient, quality oilseed with high resistance to water scarcity, soil salinity, and frost-prone areas, and it has a wide range of applications in daily life, ranging from food to pharmaceutical to industrial. Adapting high-quality oil-content-producing safflower cultivars can help reduce costs and reduce precious foreign exchange in countries like Pakistan. Exotic germplasm imported from the United States Department of Agriculture-Agricultural Research Service (USDA-ARS), consisting of 145 exotic safflower accessions and four local control cultivars were planted under semi-arid conditions in Faisalabad, Pakistan, during winter 2018-19 and 2019-20 season using an augmented design with unreplicated entries and replicated checks. Genotypic coefficient of variability (GCV) analysis revealed significant variation among the accessions of safflower for achene yield plant^-1, heads plant^-1, and branches plant^-1. The Pearson correlation analysis revealed a significant but negative correlation between days to maturity and days to 50% flowering. The results revealed larger achene yields and earlier maturity in safflower planted in early winter. Biplot analysis found that five of the tested accessions had higher achene yield plant^-1, while four of the other accessions had a higher percentage of oil than the control, which was the local safflower check-31, which had the highest oil content and best quality traits. Furthermore, the dendrogram revealed that four safflower accessions exhibited higher morphological uniqueness across the investigated traits during both years of study, which can be employed for future varietal development.