Two field experiments were performed to investigate the effect of foliar application on the productivity of bread wheat cultivars under water deficit stress conditions. The experiment focused on three bread wheat cultivars (Sakha 95, Giza 171, and Misr 1), comparing typical irrigation practices (four irrigations) against water-stressed conditions (one irrigation). Six foliar spray treatments were included in the study. The foliar applications were control, Seaweed, Ascobin, Lithovit with boron, Lithovit with nitrogen, and Cina green plus. The seasons, water treatments, and foliar spray had significant differences for most studied characters. The means of the studied traits in the 2018/19 season were significantly greater than those in 2017/18, and all studied characters significantly decreased under water stress conditions. Among the foliar applications, Cina green plus and Lithovit with nitrogen consistently yielded the most favorable results for several key indicators, including relative water content, catalase and peroxidase activity, as well as proline content. These findings were observed under both normal and water stress conditions. The study suggests that foliar applications of Cina green plus and Lithovit with nitrogen have the potential to enhance the growth and yield characteristics of wheat crops, even under drought-stress conditions. These applications might serve as potential agricultural fertilizers, mitigating the negative effects of water deficit stress on wheat plants.