Fruit peels are considered solid waste in many countries despite being organic waste that includes many beneficial nutrients for plant growth and development. The present study deals with the effect of the application of different fruit peels on the growth and anatomical features of two bitter gourd (Momordica charantia L.) varieties. For this, the pot experiment comprised six treatments, i.e., control, Banana Peel Extract (BPE), Tomato Peel Extract (TPE), Pomegranate Peel Extract (PPE), Orange Peel Extract (OPE), and MAPE (Mixture of All Peel Extract), which were applied to growing plants after a few days of germination. Their results showed that BPE application increased the plant height (61.31% and 54.04%) and shoot fresh weight (80.67% and 68.4%) in Aswad and Long Fsd, respectively. On the other hand, OPE application in Aswad and TPE in Long Fsd enhanced stem epidermal cell area (88.51% and 99.5%), xylem cell area (99.61% and 99.81%), and phloem cell area (95.27% and 99.92%), while BPE application in Aswad and MPE in Long Fsd improved root radius (17.22% and 21.87%) and cortical thickness (14.37% and 23.22%), respectively. Among all treatments, BPE and OPE showed their maximum effect in both varieties. Overall, Aswad performed better than Long Fsd.