The study evaluated the impact of five different salinities (8 dS m-1, 10 dS m-1, 12 dS m-1, 14 dS m-1, and 16 dS m-1 NACl) on quinoa varieties (Saponinsiz and Valiente). Biomass, dry matter, and some leaf anatomical characteristics such as leaf thickness, stomata number, stomata width, stomata length, and parenchyma length were investigated in the varieties during the seedling stage (April 30th, May 15th, May 29th, and June 12th). The biomass and dry matter results showed that the Saponinsiz variety was revealed to be resistant to increasing salt doses up to 14 dS m-1, while the Valiente variety was reacted to only 10 dS m-1 salt dose. The average stoma size obtained from two different quinoa varieties increased during the four different growth periods, while fluctuations were observed in the average stoma length and width. It can be said that two quinoa varieties could be efficiently cultivated at 8 dS m-1 and 10 dS m-1 salinity levels when the results are evaluated. It has emerged as an important finding that only the Saponinsiz variety can be grown efficiently in fields that have salinity rates between 8 dS m-1 and 14 dS m-1. Because of its ability to withstand lethal doses for many plants, Saponinsiz is a potential candidate for sustainable agriculture and beneficial income in arid and semi-arid areas with high salinity.