The concentrations of heavy metals (Cu, Zn, Cd, Hg and Pb) in water, soil and forages have strikingly increased in the Balikun xijiao ranches, Xinjiang, China for the latest 10 years. The concentrations of Cu, Zn, Cd, Hg and Pb in soil in polluted ranches were 6.76, 3.37, 6.77,5.76 and 11.67 times higher than those in healthy ranches. The impact of fertilized Nano-K₂MoO₄ on toxicity of heavy metal have been studied in polluted the ranches. Our findings showed that the concentrations of Mo,Se and N in forage from fertilized ranches were strikingly higher than those in the control ranches (P<0.01). The harvest and digestibility of forage in fertilized ranches were strikingly higher than those in the control ranches (P<0.01). The CP and EE in forage in fertilized the ranch were also increased strikingly (P<0.01). The concentrations of Mo and Se in blood and liver in the Altai sheep from fertilized ranches were strikingly higher than those in control ranches (P<0.01). The concentrations of Cu and Pb in blood and liver in the Altai sheep from fertilized ranches were strikingly lower than those in control ranches (P<0.01). The levels of Hb, PLT and RBC in animals from fertilized ranches were strikingly higher than those in control ranches (P<0.01). In conclusion, The fertilization of Nano-K₂MoO₄ not only strikingly increased the contents of Mo and Se in blood, but also markedly reduced the contents of Cu and Pb in blood and liver, and remarkably relieved damage from heavy metal pollution in the Altai sheep.