A safe and healthy workplace is considered to be a right for any worker/employee. The proper functioning of the Occupational Safety and Health (OHS) management system especially in the garment industry will revitalize the workers as well as increase the Indian economy. In Tamil Nadu, especially in Tirupur, there are more than 200 garment industries where approximately more than 41,200 workers are working in the spinning, weaving, ginning, garment, and dyeing sector of the garment industry. The waste material generated from the garment industry contains azo dye which could also cause health impacts on the workers which might include cancers, skin diseases, and respiratory problems. The development of the garment industry not only relies on its technical upsurge but also depends on a systematically organized occupational health and safety by its management. Among safety hazards, fire accidents and exposure to hazardous dye in the industries are the primary sources of accident and health impacts in textile industries, and preventing them would be the first and foremost criterion to run the business successfully. Hence, the present study aimed to investigate the health hazards due to azo dye discharge and assess the fire safety measures among people working in the garment industries from Tirupur district, Tamil Nadu, India. The results of the present study depicted the effect of azo dye on health aspects and the importance of fire safety in the garment industry. In conclusion, it is hoped that this study can contribute to support measures for the prevention, promotion, protection, and rehabilitation of the health of workers from garment industries.