The Klampok River, part of the Klampok sub-watershed in Semarang Regency, Central Java, faces reduced carrying capacity and water quality owing to high-intensity anthropogenic activities. This study applied the pollutant index method, based on the Ministry of Environment Regulation 115/2003, to analyze the BOD and COD concentrations in river samples. The results indicated pollution at one or all six sampling points, with the Klampok sub-watershed land classified as class III and IV, showing a land-carrying capacity deficit but a water-holding capacity surplus. The Klampok River cannot accommodate BOD and COD pollution loads in any segment, leading to a mildly to moderately polluted water quality status. SWOT and QSPM analyses suggest an aggressive and progressive management strategy for the sub-watershed, emphasizing three key components: environmental capacity, pollution regulation, and community involvement.