Releasing unsymmetrical dimethyl hydrazine (UDMH) in ambient medium is an escalating environment crisis that catches aggrandizing public concerns. Herein, a non-thermal plasma activating persulfate maneuver was introduced and its application mechanism in UDMH degradation was explored. Oxidizing kinetic experiments show that 93.8% UDMH were eliminated along with 12.5 kV, pH = 8, 50 mM NaCl, Na₂S₂O₈/UDMH (mol/mol) = 2, and 140 mL/min. The Visual MINTEQ simulated species distribution of UDMH well predicted the oxidation behaviors of UDMH in the variation of pH. Radical scavenging test integrated with UV-vis spectroscopy were introduced to identify the predominating reactive oxygen species during UDMH decomposition. The ·OH and ·SO₄^- played a synergistic role in the UDMH oxidization. Overall, this study may shed new lights on the degradation of UDMH industry wastewater using hybrid technique.