This paper presents results of a study on determination of the concentration of Cd, Pb, Cu and Zn in neoplastic and peri-neoplastic lung tissues from 110 subjects of two regions of different degrees of environmental pollution: Wielkopolska (75) and Upper Silesian Industrial District (35). The concentrations of the metals were determined by the method of differential pulse anodic stripping voltammetry (DPASV). The mean values (in mug/g wet tissue) obtained for the inhabitants from Wielkopolska were: Cd - 0.56; Pb - 0.45; Cu - 1.98; Zn - 12.93 in the neoplastic tissue and Cd - 0.88; Pb - 0.40; Cu - 1.96; Zn - 12.80 in the peri-neoplastic tissue. For the inhabitants from the Upper Silesian Industrial District (USID) the corresponding values were: Cd - 0.63; Pb - 0.25; Cu - 1.61; Zn - 20.63 in the neoplastic tissue and Cd - 1.37; Pb - 0.06; Cu - 1.66; Zn - 19.20 in the peri-neoplastic tissue. Concentrations of Cd were higher in peri-neoplastic tissues than in the neoplastic ones in the subjects from both groups. The highest concentrations of Pb and Cu were found in tissues of the inhabitants from Wielkopolska, while the highest concentrations of Cd and Zn were in tissues of those from Upper Silesian Industrial District.